ABSTRACT
Introduction: Clindamycin has been used to treat pneumoniaand soft tissue and musculoskeletal infections due to MRSA.One important problem in Clindamycin treatment is the riskof clinical failure during therapy caused by MLSB inducibleresistance. The Clinical and Laboratory Standards Institute(CLSI) suggest D-test, which is a phenotypic showingtechnique for inducible Clindamycin resistance.Material and Methods: We analyzed antimicrobialsusceptibility testing by Kirby Bauer disk diffusion method.Methicillin resistance was detected with cefoxitin (30 µg) diskand inducible clindamycin resistance was unwavering in allerythromycin resistant isolate by using D-zone test.Results: 100 S. aureus isolate 37 (36.6%) were methicillinresistant (MRSA) and 63 (63.4%) were methicillin-sensitiveS. aureus (MSSA). Although, mainstream of the MRSAisolates were imitative from pus samples 15, however, the S.aureus isolates imitative from post-operative wound infectionwere mainly MRSA 7. A total of 21 S. aureus isolates withiMLSB phenotype shown that they were 100% susceptible tovancomycin and linezolid, with modest sensitivity (71.14%) togentamicin, cefuroxime and slightest sensitivity to (23.81%)doxycycline, (20.95%) ciprofloxacin.Conclusion: Outstanding to high happening of erythromycinresistance amongst S. aureus isolates, we recommend thatD-zone test have to be regularly done in all laboratories forsuitable recommendation of clindamycin and thus preventingappearance of inducible resistant strains and managementfailure.